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A Comprehensive, Flexible Collection of SARS-CoV-2 Coding Regions

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Kim, Dae-Kyum | Knapp, Jennifer | Kuang, Da | Chawla, Aditya | Cassonnet, Patricia | Lee, Hunsang | Sheykhkarimli, Dayag | Samavarchi-Tehrani, Payman | Abdouni, Hala | Rayhan, Ashyad | Li, Roujia | Pogoutse, Oxana | Coyaud, Étienne | van Der Werf, Sylvie | Demeret, Caroline | Gingras, Anne-Claude | Taipale, Mikko | Raught, Brian | Jacob, Yves | Roth, Frederick

Edité par CCSD ; Genetics Society of America -

International audience. The world is facing a global pandemic of COVID-19 caused by the SARS-CoV-2 coronavirus. Here we describe a collection of codon-optimized coding sequences for SARS-CoV-2 cloned into Gateway-compatible entry vectors, which enable rapid transfer into a variety of expression and tagging vectors. The collection is freely available. We hope that widespread availability of this SARS-CoV-2 resource will enable many subsequent molecular studies to better understand the viral life cycle and how to block it.

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