Afficher la couverture 'Structure and function of RTX toxins | Chenal, Alexandre' en grand format
/5

0 avis

Structure and function of RTX toxins

Archive ouverte

Chenal, Alexandre | Sotomayor Pérez, Ana Cristina | Ladant, Daniel

Edité par CCSD ; Elsevier -

Chap.23. International audience. Repeat-in-ToXin (RTX) toxins are pathogenic factors produced by a wide variety of Gram-negative bacteria. These toxins are commonly known as hemolysins or leukotoxins, as they are able to form pores in the membrane of their eukaryotic target cells. The most salient structural characteristic of RTX toxins is that they have tandem repetitions of nonapeptidic motifs that constitute specific calcium-binding sites. The RTX toxins are secreted by a type I secretion system (T1SS) and fold in the presence of calcium into their active cytolytic forms. RTX toxins mainly target the immune cells and contribute to the virulence of their bacterial host.

Consulter en ligne

Suggestions

Du même auteur

Stability, structural and functional properties of a monomeric, calcium-loaded adenylate cyclase toxin, CyaA, from Bordetella pertussis.

Archive ouverte | Cannella, Sara E | CCSD

International audience. Bordetella pertussis, the causative agent of whooping cough, secretes an adenylate cyclase toxin, CyaA, which invades eukaryotic cells and alters their physiology by cAMP overproduction. Calc...

Calmodulin-induced conformational and hydrodynamic changes in the catalytic domain of Bordetella pertussis adenylate cyclase toxin.

Archive ouverte | Karst, Johanna C | CCSD

International audience. Bordetella pertussis, the causative agent of whooping cough, secretes among various toxins an adenylate cyclase (CyaA) that displays a unique mechanism of cell invasion, which involves a dire...

Calmodulin fishing with a structurally disordered bait triggers CyaA catalysis

Archive ouverte | O'Brien, Darragh P. | CCSD

International audience. Once translocated into the cytosol of target cells, the catalytic domain (AC) of the adenylate cyclase toxin (CyaA), a major virulence factor of Bordetella pertussis, is potently activated by...

Chargement des enrichissements...