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Viral Load Increases in SJL/J Mice Persistently Infected by Theiler's Virus after Inactivation of the 2m Gene

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Aubagnac, Stéphanie | Brahic, Michel | Bureau, Jean-François

Edité par CCSD ; American Society for Microbiology -

International audience. We show that inactivating the beta(2)m gene increases the viral load of SJL/J mice persistently infected by Theiler's virus. Together with previous results, this shows that the characteristics of Tmevp1, a locus which controls the amount of viral RNA that persists in the central nervous system, are those of an H-2 class I gene.

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