Syracuse

A Multi-country Evaluation of Neisseria meningitidis Serogroup B Factor H–Binding Proteins and Implications for Vaccine Coverage in Different Age Groups.

Archive ouverte

Hoiseth, Susan | Murphy, Ellen | Andrew, Lubomira | Vogel, Ulrich | Frosch, Matthias | Hellenbrand, Wiebke | Abad, Raquel | Vazquez, Julio, A | Borrow, Ray | Findlow, Jamie | Taha, Muhamed-Kheir | Deghmane, Ala-Eddine | Caugant, Dominique, A | Kriz, Paula | Musilek, Martin | Mayer, Leonard, W | Wang, Xin | Macneil, Jessica | York, Laura | Tan, Charles | Jansen, Kathrin, U. | Anderson, Annaliesa, S.

Edité par CCSD ; Lippincott, Williams & Wilkins -

International audience. BACKGROUND:Recombinant vaccines containing factor H-binding protein (fHBP) have been developed for the purpose of protection from invasive meningococcal serogroup B disease. Neisseria meningitidis fHBP sequences can be divided into 2 genetically and immunologically distinct subfamilies (A and B); thus, cross protection is conferred within but not between subfamilies. A comprehensive understanding of fHBP epidemiology is required to accurately assess the potential vaccine impact when considering different vaccination implementation strategies.METHODS:Systematically collected invasive meningococcal serogroup B isolates from England, Wales, Northern Ireland, the United States, Norway, France and the Czech Republic were previously characterized for fHBP sequence. This study expanded the evaluation with additional meningococcal serogroup B disease isolates from Spain (n = 346) and Germany (n = 205). This expanded set (n = 1841), collected over a 6-year period (2001 to 2006), was evaluated for fHBP sequence and fHBP subfamily relative to patient age.RESULTS:All 1841 isolates contained fhbp. fHBP sequences from Spain and Germany fell within the previously described subfamilies, with 69% of isolates belonging to subfamily B and 31% to subfamily A; prevalent sequence variants were also similar. Stratification of data by age indicated that disease in infants <1 year of age was caused by a significantly higher proportion of isolates with fHBP subfamily A variants than that seen in adolescents and young adults 11-25 years (47.7% versus 19.5%, P < 0.0001, respectively).CONCLUSIONS:These observations highlight a difference in epidemiology of fHBP subfamilies in different age groups, with fHBP subfamily A strains causing more disease in vulnerable populations, such as infants, than in adolescents.

• Description
• Sujet/Public
• Outil
• Outil d'anticipation
• Mémoire et thèse
• Gestion