Human Adaptation of Ebola Virus during the West African Outbreak

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Urbanowicz, Richard, A | Mcclure, C Patrick | Sakuntabhai, Anavaj | Sall, Amadou, Alpha | Kobinger, Gary | Müller, Marcel, A | Holmes, Edward, C | Rey, Felix | Simon-Loriere, Etienne | Ball, Jonathan, K.

Edité par CCSD ; Elsevier -

International audience. Graphical Abstract Highlights d EBOV adapted to humans during the West African outbreak d Amino acid substitutions in the EBOV glycoprotein increase human cell tropism d The same glycoprotein amino acid substitutions decrease tropism for bat cells In Brief The Ebola virus acquired amino acid substitutions in its glycoprotein that increased its tropism for human cells during the West African outbreak of 2013-2016.

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