Syracuse

Manipulation of host membranes by the bacterial pathogens Listeria, Francisella, Shigella and Yersinia.

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Pizarro-Cerdá, Javier | Charbit, Alain | Enninga, Jost | Lafont, Frank | Cossart, Pascale

Edité par CCSD ; Elsevier -

International audience. Bacterial pathogens display an impressive arsenal of molecular mechanisms that allow survival in diverse host niches. Subversion of plasma membrane and cytoskeletal functions are common themes associated to infection by both extracellular and intracellular pathogens. Moreover, intracellular pathogens modify the structure/stability of their membrane-bound compartments and escape degradation from phagocytic or autophagic pathways. Here, we review the manipulation of host membranes by Listeria monocytogenes, Francisella tularensis, Shigella flexneri and Yersinia spp. These four bacterial model pathogens exemplify generalized strategies as well as specific features observed during bacterial infection processes.

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