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The pathological effects of Heminecrolysin, a dermonecrotic toxin from Hemiscorpius lepturus scorpion venom are mediated through its lysophospholipase D activity.

Archive ouverte | Borchani, Lamia | CCSD

International audience. We have previously identified Heminecrolysin, a sphingomyelinase D (SMaseD), as the major protein responsible for the main pathological effects observed following Hemiscorpius (H.) lepturus s...

Bot IT2: a new scorpion toxin to study receptor site on insect sodium channels

Archive ouverte | Cestèle, Sandrine | CCSD

International audience. The insect-specific Bothus occitanus tunetanus IT2 toxin is distinguishable from other scorpion toxins by its amino acid sequence and effects on sodium conductance. The present study reveals ...

Heminecrolysin, a potential immunogen for monospecific antivenom production against Hemiscorpius lepturus scorpion.

Archive ouverte | Borchani, Lamia | CCSD

International audience. Serotherapy against Hemiscorpius (H.) lepturus scorpion sting is based on the administration of equine polyvalent antivenom prepared against a mixture of six venoms. In a previous study, we r...

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