Combined medico-surgical strategy for invasive sino-orbito-cerebral breakthrough fungal infection with Hormographiella aspergillata in an acute leukaemia patient

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Heiblig, M. | Bozzoli, V. | Saison, J. | Thomas, X. | de Croze, D. | Traverse-Glehen, A. | Cosmidis, A. | Chidiac, C. | Ferry, Tristan | Alanio, Alexandre | Bienvenu, A. L. | Dupont, Didier | Ducastelle-Lepretre, S. | Michallet, M. | Ader, Florence | Group, Lyon Heminf Study

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International audience. Hormographiella aspergillata is a rare causative agent of invasive filamentous breakthrough infection, mostly arising after echinocandin exposure. We report a neutropenic patient who developed a severe sino-orbito-cerebral H. aspergillata infection while receiving empirical caspofungin, successfully controlled by an aggressive strategy associating surgical debridement and combined high-dose regimen of antifungal drugs.

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