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Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action.

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Fioravanti, Rossella | Celestino, Ignacio | Costi, Roberta | Cuzzucoli Crucitti, Giuliana | Pescatori, Luca | Mattiello, Leonardo | Novellino, Ettore | Checconi, Paola | Palamara, Anna Teresa | Nencioni, Lucia | Di Santo, Roberto

Edité par CCSD ; Elsevier -

International audience. A set of polyphenol compounds was synthesized and assayed for their ability in inhibiting influenza A virus replication. A sub-set of them showed low toxicity. The best compounds within this sub-set were 4 and 6g, which inhibited the viral replication in a dose-dependent manner. The antiviral activity of these molecules was demonstrated to be caused by their interference with intracellular pathways exploited for viral replication: (1) MAP kinases controlling nuclear-cytoplasmic traffic of viral ribonucleoprotein complex; (2) redox-sensitive pathways, involved in maturation of viral hemagglutinin protein.

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