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Determination of natural versus laboratory human infection with Mayaro virus by molecular analysis.

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Junt, Tobias | Heraud, Jean-Michel | Lelarge, J. | Labeau, B. | Talarmin, Antoine

Edité par CCSD ; Cambridge University Press (CUP) -

A laboratory worker developed clinical signs of infection with Mayaro virus (Togaviridae), an arbovirus of South and Central America, 6 days after preparation of Mayaro viral antigen and 10 days after a trip to a rain forest. There was no evidence of skin lesions during the antigen preparation, and level 3 containment safety measures were followed. Therefore, molecular characterization of the virus was undertaken to identify the source of infection. RT-PCR and DNA sequence comparisons proved the infection was with the laboratory strain. Airborne Mayaro virus contamination is thus a hazard to laboratory personnel.

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