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CpG Inhibits Pro-B Cell Expansion through a Cathepsin B-Dependent Mechanism.

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Lalanne, Ana Inés | Moraga, Ignacio | Hao, Yi | Pereira, João Pedro | Alves, Nuno L. | Huntington, Nicholas D. | Freitas, Antonio A. | Cumano, Ana | Vieira, Paulo

Edité par CCSD ; Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists -

International audience. TLR9 is expressed in cells of the innate immune system, as well as in B lymphocytes and their progenitors. We investigated the effect of the TLR9 ligand CpG DNA on the proliferation of pro-B cells. CpG DNA inhibits the proliferation of pro-B, but not pre-B, cells by inducing caspase-independent cell death through a pathway that requires the expression of cathepsin B. This pathway is operative in Rag-deficient mice carrying an SP6 transgene, in which B lymphopoiesis is compromised, to reduce the size of the B lymphocyte precursor compartments in the bone marrow. Thus, TLR9 signals can regulate B lymphopoiesis in vivo.

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