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Pre-B cell receptor expression is necessary for thymic stromal lymphopoietin responsiveness in the bone marrow but not in the liver environment

Archive ouverte | Vosshenrich, Christian A. J. | CCSD

International audience. IL-7 and thymic stromal lymphopoietin (TSLP) are two major cytokines controlling murine B cell development. IL-7 has been studied extensively, but only recently has it become possible to unra...

Inhibitors of DNA Binding Proteins Restrict T Cell Potential by Repressing Notch1 Expression in Flt3-Negative Common Lymphoid Progenitors.

Archive ouverte | Pereira de Sousa, Ana | CCSD

International audience. Lineage commitment is regulated during hematopoiesis, with stepwise loss of differentiation potential ultimately resulting in lineage commitment. In this study we describe a novel population ...

CpG Inhibits Pro-B Cell Expansion through a Cathepsin B-Dependent Mechanism.

Archive ouverte | Lalanne, Ana Inés | CCSD

International audience. TLR9 is expressed in cells of the innate immune system, as well as in B lymphocytes and their progenitors. We investigated the effect of the TLR9 ligand CpG DNA on the proliferation of pro-B ...

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