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B cell positive selection by self antigens and counter-selection of dual B cell receptor cells in the peripheral B cell pools.

Archive ouverte | Rosado, Maria Manuela | CCSD

International audience. The presence of B cells expressing two B cell receptors (BCR), described in BCR-transgenic, gene-targeted and normal mice, may represent an autoimmune hazard. We generated RAG-2-deficient mic...

The role of the B cell receptor V region in peripheral B cell survival.

Archive ouverte | Rosado, Maria Manuela | CCSD

We investigate the role of the antigen-specific B cell receptor (BCR) in the establishment and maintenance of the peripheral B cell pools. We studied the fate of a population of transgenic B cells expressing a BCR without V region...

The role of cellular competition in B cell survival and selection of B cell repertoires.

Archive ouverte | Freitas, Antonio A. | CCSD

International audience. We studied the competitive repopulation by different B cells of irradiated mice reconstituted with bone marrow from either congenic or Ig-transgenic (TG) mice mixed at different ratios. We fo...

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