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Exogenous chromosomes reveal how sequence composition drives chromatin assembly, activity, folding and compartmentalization

Archive ouverte | Chapard, Christophe | CCSD

v3, 31 octobre 2023. Genomic sequences co-evolve with DNA-associated proteins to ensure the multiscale folding of long DNA molecules into functional chromosomes. In eukaryotes, different molecular complexes organize...

Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus

Archive ouverte | Meneu, Léa | CCSD

International audience. In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous load...

Nucleosome positioning on large tandem DNA repeats of the ’601’ sequence engineered in Saccharomyces cerevisiae

Archive ouverte | Lancrey, Astrid | CCSD

International audience. The so-called 601 DNA sequence is often used to constrain the position of nucleosomes on a DNA molecule in vitro. Although the ability of the 147 base pair sequence to precisely position a nu...

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