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Corynanthean-Epicatechin Flavoalkaloids from Corynanthe pachyceras

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Kouamé, Tapé | Okpekon, Aboua Timothée | Bony, Nicaise | N’tamon, Amon Diane | Gallard, Jean-François | Rharrabti, Somia | Leblanc, Karine | Mouray, Elisabeth | Grellier, Philippe | Champy, Pierre | Beniddir, Mehdi, A | Le Pogam, Pierre

Edité par CCSD ; MDPI -

International audience. Epicatechocorynantheines A and B, and epicatechocorynantheidine were isolated from the stem bark of Corynanthe pachyceras. These molecules were pinpointed, and their isolation streamlined, by a molecular networking strategy. The structural elucidation was unambiguously accomplished from HRMS and 1D/2D NMR data. These compounds represent the first examples of corynanthean-type alkaloids tethered with a flavonoid. Epicatechocorynantheidine notably instigated two connections between the monoterpene indole alkaloid and the flavonoid, yielding an unprecedented octacyclic appendage. These flavoalkaloids exerted moderate antiplasmodial activities.

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