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Migratory phase of Litomosoides sigmodontis filarial infective larvae is associated with pathology and transient increase of S100A9 expressing neutrophils in the lung

Archive ouverte | Karadjian, Gregory | CCSD

Filarial infections are tropical diseases caused by nematodes of the Onchocercidae family such as Mansonella perstans. The infective larvae (L3) are transmitted into the skin of vertebrate hosts by blood-feeding vectors. Many fila...

CXCR4 signaling controls dendritic cell location and activation at steady state and in inflammation

Archive ouverte | Gallego, Carmen | CCSD

International audience. Dendritic cells (DCs) encompass several cell subsets that collaborate to initiate and regulate immune responses. Proper DC localization determines their function and requires the tightly cont...

IL-4 receptor dependent expansion of lung CD169 + macrophages in microfilaria-driven inflammation

Archive ouverte | Fercoq, Fréderic | CCSD

International audience. Lung disease is regularly reported in human filarial infections but the molecular pathogene-sis of pulmonary filariasis is poorly understood. We used Litomosoides sigmodontis, a rodent filari...

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