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WED-475 Optimal strategies for eliminating mother-to-child transmission of hepatitis B in Burkina Faso

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Gosset, Andréa | Nayagam, Shevanthi | Boyer, Sylvie | Guingané, Alice | Schmit, Nora | Tiendrebeogo, Abdoul Salam Eric | Kania, Dramane | Carrieri, Patrizia | Shimakawa, Yusuke | Hallett, Timothy

Edité par CCSD -

International audience. The baseline strategy was the current situation where HepB-BD is administrated alongside HepB3. Costs were assessed from the Burkina Faso government's perspective, including costs of intervention strategies, HBV vaccination with the birth dose (HepB-BD), and care for advanced HBV disease. A deterministic compartmental dynamic model stratified by age, sex, and transmission mode was used. An epidemiological model implemented the strategies from 2024 to 2124, while a cost-effectiveness model included strategy implementation in 2024 with a health impact assessment over a 100-year horizon. The cost-effectiveness threshold was half of 2022 GDP per capita (US$416.5) and the discount rate was 3%. Deterministic and probabilistic sensitivity analyses were conducted.

Conclusions

The Treat All strategy was the optimal strategy to eliminate HBV MTCT as quickly as possible.

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