Gut microb-aging and its relevance to frailty aging

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Le Cosquer, Guillaume | Vergnolle, Nathalie | Motta, Jean-Paul

Edité par CCSD ; Elsevier -

International audience. This review explores 'microb-aging' in the gut and its potential link to frailty aging. We explore this connection through alterations in microbiota's taxonomy and metabolism, as well as with concepts of ecological resilience, pathobionts emergence, and biogeography. We examine microb-aging in interconnected body organs, emphasizing the bidirectional relationship with 'inflammaging'. Finally, we discuss how targeting microb-aging could improve screening, diagnostic, and therapeutic approaches in geriatrics.

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