Insights into the modulation of the interferon response and NAD⁺in the context of COVID-19

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Habeichi, Nada, J | Tannous, Cynthia | Yabluchanskiy, Andriy | Altara, Raffaele | Mericskay, Mathias | Booz, George, W | Zouein, Fouad, A

Edité par CCSD ; Informa Healthcare -

International audience. The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in dramatic worldwide mortality. Along with developing vaccines, the medical profession is exploring new strategies to curb this pandemic. A better understanding of the molecular consequences of SARS-CoV-2 cellular infection could lead to more effective and safer treatments. This review discusses the potential underlying impact of SARS-CoV-2 in modulating interferon (IFN) secretion and in causing mitochondrial NAD + depletion that could be directly linked to COVID-19's deadly manifestations. What is known or surmised about an imbalanced innate immune response and mitochondrial dysfunction post-SARS-CoV-2 infection, and the potential benefits of well-timed IFN treatments and NAD + boosting therapies in the context of the COVID-19 pandemic are discussed.

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