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Human model of IRX5 mutations reveals key role for this transcription factor in ventricular conduction

Archive ouverte | Al Sayed, Zeina | CCSD

International audience. Aim: Several inherited arrhythmic diseases have been linked to single gene mutations in cardiac ion channels and interacting proteins. However, the mechanisms underlying most arrhythmias, are...

Generation of three human induced pluripotent stem cell lines with IRX5 knockout and knockin genetic editions using CRISPR-Cas9 system

Archive ouverte | Canac, Robin | CCSD

International audience. Studies on animal models have shown that Irx5 is an important regulator of cardiac development and that it regulates ventricular electrical repolarization gradient in the adult heart. Mutatio...

RRAD mutation causes electrical and cytoskeletal defects in cardiomyocytes derived from a familial case of Brugada syndrome

Archive ouverte | Belbachir, Nadjet | CCSD

International audience. Aims : The Brugada syndrome (BrS) is an inherited cardiac disorder predisposing to ventricular arrhythmias. Despite considerable efforts, its genetic basis and cellular mechanisms remain larg...

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