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TP53 mutations at codon 234 are associated with chlorambucil treatment in chronic lymphocytic leukemia

Archive ouverte | Lazarian, Grégory | CCSD

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Archive ouverte | Lazarian, Grégory | CCSD

International audience. TP53 aberrations are a major predictive factor of resistance to chemoimmunotherapy in chronic lymphocytic leukemia (CLL), and an assessment of them before each line of treatment is required f...

The Broad Spectrum of TP53 Variants in CLL: NGS Analysis of 573 Pathogenic TP53 Variants

Archive ouverte | Lazarian, Gregory | CCSD

International audience. TP53 aberrations, including somatic mutations of TP53 gene or 17p deletion leading to the loss of the TP53 locus, are a major predictive factor of resistance to fludarabin based chemotherapy ...

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