Beclin-1 increases with obstructive sleep apnea severity

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Schlemmer, Frédéric | Zysman, Maéva | Ribeiro Baptista, Bruno | Audureau, Etienne | Covali Noroc, Ala | Ridoux, Audrey | Derumeaux, Geneviève | Adnot, Serge | Maitre, Bernard | Le Corvoisier, Philippe | Lanone, Sophie | Boczkowski, Jorge | Boyer, Laurent

Edité par CCSD ; Elsevier -

International audience. Obstructive sleep apnea is a common chronic disorder that leads to chronic intermittent hypoxia described as an important factor contributing to the pathogenesis of OSA-related comorbidities. Besides, recent data suggest that intermittent hypoxia can induce adaptative cardiovascular pathways inducing a relative resistance to ischemic insults. Adaptative pathways induced by hypoxia could implicate autophagic processes and Beclin-1, one of the first mammalian autophagy effectors. Thus, activation of autophagy could protect against cardiovascular events in patients with OSA and could be considered as biomarker of a better prognosis.

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