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Frequent Homozygous Deletions of Type I Interferon Genes in Pleural Mesothelioma Confer Sensitivity to Oncolytic Measles Virus

Archive ouverte | Delaunay, Tiphaine | CCSD

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Frequent Homozygous Deletions of Type I Interferon Genes in Pleural Mesothelioma Confer Sensitivity to Oncolytic Measles Virus. Frequent Homozygous Deletions of Type I Interferon Genes in Pleural Mesothelioma Confer Sensitivity to Oncolytic Measles Virus: Interferon genes loss sensitizes tumor cells to viral lysis

Archive ouverte | Delaunay, Tiphaine | CCSD

International audience. Oncolytic immunotherapy is based on the use of non-pathogenic replicative oncolytic viruses (OV) that infect and kill exclusively tumor cells. Recently, we showed that the spontaneous oncolyt...

Involvement of the M-CSF/IL-34/CSF- 1R pathway in malignant pleural mesothelioma

Archive ouverte | Blondy, Thibaut | CCSD

International audience. Background: Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer related to asbestos exposure. The tumor microenvironment content, particularly the presence of macrophages, wa...

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