Colistin–glycopeptide combinations against multidrug-resistant Acinetobacter baumannii in a mouse model of pneumonia

0 avis

Colistin–glycopeptide combinations against multidrug-resistant Acinetobacter baumannii in a mouse model of pneumonia

Archive ouverte

Edité par CCSD ; Future Medicine -

International audience. Aim: To assess the effect of colistin-glycopeptide combination against a multidrug-resistant strain of Acinetobacter baumannii. Materials & methods: We used in vitro procedures (Etest method, checkerboard test and kill-time assays) and a mouse model of a carbapenem-resistant A. baumannii pneumonia. Results: The colistin-teicoplanin combination allowed a 74% increase of the survival in the mouse model within the 4 days following bacterial inoculation as compared with saline or colistin alone (p = 0.06). Concurrently, the colistin-vancomycin combination presented a similar efficacy as compared with saline or colistin alone in the mouse model. Conclusion: According to those preliminary results, using the colistin-teicoplanin combination in therapeutic deadlocks encountered in certain multiresistant A. baumannii pneumonia could be envisaged if the results are confirmed.

Langue: en

Indexation

Consulter en ligne

Consulter le document

Suggestions

Du même auteur

Iterative fecal microbiota transplantations for eradicating digestive colonization with carbapenemase-producing Enterobacteriaceae: is it worth it?

Archive ouverte | Mahieu, Rafael | CCSD

International audience. Carbapenemase-producing Enterobacteriaceae (CPE) have emerged as a major source of bacterial resistance and their dissemination is a serious public health threat.1 It has also been demonstrat...

Impact of ceftriaxone and temocillin on fecal abundance of extended-spectrum β-lactamase producing Escherichia coli in a mouse model

Archive ouverte | Chenouard, Rachel | CCSD

International audience. Background: Gut colonization by ESBL-producing Enterobacteriaceae (ESBL-PE) is widespread and is promoted by antibiotic exposure. Higher fecal abundance of ESBL-PE promotes the dissemination ...

BIOFIRE® Blood Culture IDentification 2 (BCID2) panel for early adaptation of antimicrobial therapy in adult patients with bloodstream infections: a real-life experience

Archive ouverte | Donnars, Anne | CCSD

International audience. Our objective was to assess the effectiveness of a multiplex PCR panel for blood culture identification (BCID2) on the implementation of appropriate antimicrobial therapy. We conducted a mono...

Chargement des enrichissements...