Unaltered regulatory B-cell frequency and function in patients with multiple sclerosis

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Michel, Laure | Chesneau, Mélanie | Manceau, Philippe | Genty, Athénaïs | Garcia, Alexandra | Salou, Marion | Ngono, Annie, Elong | Pallier, Annaïck | Jacq-Foucher, Marylène | Lefrère, Fabienne | Wiertlewski, Sandrine | Soulillou, Jean-Paul | Degauque, Nicolas | Laplaud, David-Axel | Brouard, Sophie

Edité par CCSD ; Elsevier -

International audience. Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS) typically characterized by the recruitment of T cells into the CNS. However, certain subsets of B cells have been shown to negatively regulate autoimmune diseases and some data support a prominent role for B cells in MS physiopathology. For B cells in MS patients we analyzed subset frequency, cytokine secretion ability and suppressive properties. No differences in the frequencies of the B-cell subsets or in their ability to secrete cytokines were observed between MS and healthy volunteers (HV). Prestimulated B cells from MS patients also inhibited CD4 + CD25 − T cell proliferation with a similar efficiency as B cells from HV. Altogether, our data show that, in our MS patient cohort, regulatory B cells have conserved frequency and function.

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