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Metabolic pathways regulate the migration of TEMRA CD8 to inflammatory site

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Doan-Ngoc, Tra-My | Tilly, Gaëlle | Bruneau, Sarah | Glemain, Alexandre | Brouard, Sophie | Pecqueur, Claire | Degauque, Nicolas

Edité par CCSD -

International audience. Background. Accumulation of TEMRA CD8 (CD45RA+CCR7-CD28-CD27-) in kidney transplant recipients (KTR) with a stable graft function is associated with an increased risk of kidney graft dysfunction. Upon TCR and IL-15 stimulation, TEMRA CD8 activates the endothelium by secreting high amount of IFNɣ and TNFα.Aim. Migration of T cells to inflamed tissue is crucial for their immune effector function, especially in the context of transplantation. In this study, we aim to characterize the migratory properties of TEMRA CD8 from KTR by analysing their adhesion and their transmigration across endothelial cell barrier and we investigate the ability of metabolic interferences to prevent the migration of TEMRA CD8 to inflamed site.

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