Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies

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Lord, Phillip | Spiering, Rachel | Aguillon, Juan, C | Anderson, Amy, E | Appel, Silke | Benitez-Ribas, Daniel | ten Brinke, Anja | Broere, Femke | Cools, Nathalie | Cuturi, Maria, Cristina | Diboll, Julie | Geissler, Edward, K | Giannoukakis, Nick | Gregori, Silvia | Marieke van Ham, S | Lattimer, Staci | Marshall, Lindsay | Harry, Rachel, A | Hutchinson, James, A | Isaacs, John, D | Joosten, Irma | van Kooten, Cees | Lopez Diaz de Cerio, Ascension | Nikolic, Tatjana | Barbaros Oral, Haluk | Sofronic-Milosavljevic, Ljiljana | Ritter, Thomas | Riquelme, Paloma | Thomson, Angus, W | Trucco, Massimo | Vives-Pi, Marta | Martinez-Caceres, Eva, M | Hilkens, Catharien M.U.

Edité par CCSD ; PeerJ -

International audience. Cellular therapies with tolerogenic antigen-presenting cells (tolAPC) show great promiseforthetreatmentofautoimmunediseasesandforthepreventionofdestructive immune responses after transplantation. The methodologies for generating tolAPC vary greatly between different laboratories, making it difficult to compare data from differentstudies;thusconstitutingamajorhurdleforthedevelopmentofstandardised tolAPCtherapeuticproducts.HerewedescribeaninitiativebymembersofthetolAPC field to generate a minimum information model for tolAPC (MITAP), providing a reporting framework that will make differences and similarities between tolAPC productstransparent.Inthisway,MITAPconstitutesafirstbutimportantsteptowards the production of standardised and reproducible tolAPC for clinical application.

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