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The Free Fatty Acid Receptor G Protein-coupled Receptor 40 (GPR40) Protects from Bone Loss through Inhibition of Osteoclast Differentiation

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Wauquier, Fabien | Philippe, Claire | Léotoing, Laurent | Mercier, Sylvie | Davicco, Marie-Jeanne | Lebecque, Patrice | Guicheux, Jérôme | Pilet, Paul | Miot-Noirault, Elisabeth | Poitout, Vincent | Alquier, Thierry | Coxam, Véronique | Wittrant, Y.

Edité par CCSD ; American Society for Biochemistry and Molecular Biology -

International audience. Background: Long chain fatty acids have been shown to activate the membrane-bound receptor GPR40.Results: GPR40 agonist alters bone-resorbing cell differentiation through inhibition of the NF-B system.Conclusion: GPR40 exerts protective effects in vivo on bone tissue.Significance: GPR40 is a nutritional and therapeutic target opening up new avenues for clinical investigations in terms of metabolic and age-related bone disorders.

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