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Lomustine is beneficial to older AML with ELN2017 adverse risk profile and intermediate karyotype: a FILO study

Archive ouverte | Largeaud, Laetitia | CCSD

International audience. We previously reported the benefit of lomustine addition to conventional chemotherapy in older acute myeloid leukemias with nonadverse chromosomal aberrations in the LAM-SA 2007 randomized cl...

Routine use of microarray-based gene expression profiling to identify patients with low cytogenetic risk acute myeloid leukemia: accurate results can be obtained even with suboptimal samples.

Archive ouverte | de La Blétière, Diane Raingeard | CCSD

International audience. UNLABELLED: ABSTRACT: BACKGROUND: Gene expression profiling has shown its ability to identify with high accuracy low cytogenetic risk acute myeloid leukemia such as acute promyelocytic leukem...

Horizontal meta-analysis identifies common deregulated genes across AML subgroups providing a robust prognostic signature

Archive ouverte | Nehme, A | CCSD

International audience. Key Points • AML cytogenetic subgroups share a set of 330 altered genes that correlate with myeloid differentiation, leukemic stemness, and relapse. • The unbiased CODEG22 score, including 4 ...

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