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Pleural Effusions from Patients with Mesothelioma Induce Recruitment of Monocytes and Their Differentiation into M2 Macrophages

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Chéné, Anne-Laure | D’almeida, Sènan | Blondy, Thibaut | Tabiasco, Julie | Deshayes, Sophie | Fonteneau, Jean-François | Cellerin, Laurent | Delneste, Yves | Grégoire, Marc | Blanquart, Christophe

Edité par CCSD ; Lippincott, Williams & Wilkins -

International audience. Introduction: Mesothelioma is a rare and aggressive cancer related to asbestos exposure. We recently showed that pleural effusions (PEs) from patients with mesothelioma contain high levels of the CC motif chemokine ligand 2 (CCL2) inflammatory chemokine. In the present work, we studied the effect of CCL2 contained in mesothelioma samples , particularly on monocyte recruitment. Then, we studied the fate of these monocytes in malignant pleural mesotheli-oma (MPM) PEs and their impact on tumor cells' properties.

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