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P2rx7 deficiency does not alter subretinal Mononuclear Phagocytes recruitment nor photoreceptor loss 4 days after retinal detachment.

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Hu, Shulong J | Calippe, Bertrand | Lavalette, Sophie | Roubeix, Christophe | Montassar, Fadoua | Housset, Michael | Levy, Olivier | Delarasse, Cecile | Paques, Michel | Sahel, José-Alain | Sennlaub, Florian | Guillonneau, Xavier

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Referenced in J Neurosci as URL. To investigate whether P2rx7 inhibition prevented photoreceptor toxicity of C57BL/6J-Mononucelar phagocytes (MPs), we submitted C57BL/6J and P2rx7-/- mice to experimental retinal detachment, where subretinal C57BL/6J-MPs have been shown to participate in photoreceptor degeneration (Nakazawa et al., 2007). C57BL/6J and P2rx7-/- mice exhibit similar subretinal MP accumulation but showed no difference in the number of TUNEL positive photoreceptor cells under these conditions.

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