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Joining forces: first application of a rapamycin-induced dimerizable Cre system for conditional null mutant analysis in Leishmania.

Archive ouverte | Späth, Gerald F | CCSD

International audience. Reverse genetics in Leishmania spp has gained importance beyond basic research as efforts increase to discover and validate new drug targets. Often, the most promising targets are essential f...

GIP: an open-source computational pipeline for mapping genomic instability from protists to cancer cells

Archive ouverte | Späth, Gerald F | CCSD

International audience. Abstract Genome instability has been recognized as a key driver for microbial and cancer adaptation and thus plays a central role in many diseases. Genome instability encompasses different ty...

Hepatocyte nuclear factor 4 expression overcomes repression of the hepatic phenotype in dedifferentiated hepatoma cells.

Archive ouverte | Späth, Gerald F | CCSD

International audience. The capacity of the liver-enriched transcription factor hepatocyte nuclear factor 4 (HNF4) to direct redifferentiation of dedifferentiated rat hepatoma cells was investigated by stable transf...

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