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Loss of STOP protein impairs peripheral olfactory neurogenesis.

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Benardais, Karelle | Kasem, Basem | Couegnas, Alice | Samama, Brigitte | Fernandez, Sebastien | Schaeffer, Christiane | Antal, Maria-Cristina | Job, Didier | Schweitzer, Annie | Andrieux, Annie | Giersch, Anne | Nehlig, Astrid | Boehm, Nelly

Edité par CCSD ; Public Library of Science -

International audience. In conclusion, STOP protein seems to be involved in the establishment of synapses in the olfactory glomerulus. Our results indicate that the olfactory system of STOP null mice is a well-suited experimental model (1) for the study of the mechanism of action of STOP protein in synaptic function/plasticity and (2) for pathophysiological studies of the mechanisms of altered neuronal connections in schizophrenia.

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