Therapy-induced tumor immunosurveillance involves IFN-producing killer dendritic cells.

0 avis

Therapy-induced tumor immunosurveillance involves IFN-producing killer dendritic cells.

Archive ouverte

Edité par CCSD ; American Association for Cancer Research -

International audience. A unique class of IFN-producing killer dendritic cells (IKDC) resembling natural killer cells has been defined that can recognize and lyse tumor cells through a tumor necrosis factor-related apoptosis-inducing ligand-dependent mechanism. IKDC may mediate the host-dependent antitumor activity of Gleevec/STI571 and other therapeutics that can inhibit the c-kit tyrosine kinase. IKDC represent an important new component of the innate immune system responding to cancer.

Langue: en

Indexation

Consulter en ligne

Consulter le document

Suggestions

Du même auteur

Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death. A novel dendritic cell subset involved in tumor immunosurveillance

Archive ouverte | Taieb, Julien | CCSD

International audience. Systemic anticancer chemotherapy is immunosuppressive and mostly induces nonimmunogenic tumor cell death. Here, we show that even in the absence of any adjuvant, tumor cells dying in response...

The critical role of IL-15 in the antitumor effects mediated by the combination therapy imatinib and IL-2.

Archive ouverte | Mignot, Grégoire | CCSD

International audience. The synergistic antitumor effects of the combination therapy imatinib mesylate (IM) and IL-2 depended upon NK1.1- expressing cells and were associated with the accumulation of CD11c(int)B220(...

Dendritic cells and innate defense against tumor cells.

Archive ouverte | Ullrich, Evelyn | CCSD

International audience. Tumor growth results from a delicate balance between intrinsic dysregulation of oncogenes, tumor suppressor and stability genes counteracted by extrinsic defenses composed of immune cells sha...

Chargement des enrichissements...