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β-arrestin-1 participates in thrombosis and regulates integrin aIIbβ3 signalling without affecting P2Y receptors desensitisation and function.. β-arrestin-1 participates in thrombosis and regulates integrin aIIbβ3 signalling without affecting P2Y receptors desensitisation and function.: Role of β-arrestins in platelet function

Archive ouverte | Schaff, Mathieu | CCSD

International audience. β-arrestin-1 (β-arr1) and β-arrestin-2 (β-arr2) are cytosolic proteins well-known to participate in G protein-coupled receptor desensitisation and signalling. We used genetically-inactivated ...

Identification of five novel 14‐3‐3 isoforms interacting with the GPIb–IX complex in platelets

Archive ouverte | Mangin, Pierre Henri | CCSD

International audience. Background: Binding of von Willebrand factor to the platelet glycoprotein (GP)Ib-IX complex initiates a signaling cascade leading to integrin alpha(IIb)beta(3) activation, a key process in he...

Imaging thrombosis with (99m)Tc-labeled RAM.1-antibody in vivo

Archive ouverte | Ouadi, Ali | CCSD

Introduction: Platelets play a major role in thrombo-embolic diseases, notably by forming a thrombus that can ultimately occlude a vessel. This may provoke ischemic pathologies such as myocardial infarction, stroke or peripheral a...

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