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Dual and beneficial roles of macrophages during skeletal muscle regeneration.

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Chazaud, Bénédicte | Brigitte, Madly | Yacoub-Youssef, Houda | Arnold, Ludovic | Gherardi, Romain | Sonnet, Corinne | Lafuste, Peggy | Chretien, Fabrice

Edité par CCSD ; American College of Sports Medicine -

International audience. Macrophages are necessary for skeletal muscle regeneration after injury. Muscle recruits inflammatory monocytes/macrophages that switch toward an anti-inflammatory profile upon phagocytosis of debris. In vitro, proinflammatory macrophages stimulate myoblast proliferation, whereas anti-inflammatory macrophages stimulate their differentiation. Thus, macrophages are involved in both phases of skeletal muscle regeneration: first, inflammation and cleansing of necrosis, and then myogenic differentiation and tissue repair.

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