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Dendritic cells and innate defense against tumor cells.

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Ullrich, Evelyn | Ménard, Cédric | Flament, Caroline | Terme, Magali | Mignot, Grégoire | Bonmort, Mathieu | Plumas, Joël | Chaperot, Laurence | Chaput, Nathalie | Zitvogel, Laurence

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International audience. Tumor growth results from a delicate balance between intrinsic dysregulation of oncogenes, tumor suppressor and stability genes counteracted by extrinsic defenses composed of immune cells shaping tumor immunogenicity. Although immune subversion might be the ultimate outcome of this process, a complex network of cellular interactions take place eventually leading to tumor specific cognate immune responses. The links between innate and cognate antitumor immunity eliciting protective T cell responses are instigated by cytokines, chemokines and damage associated molecular patterns. The intricate differentiation pathway whereby dendritic cells could undergo an efficient maturation program in the tumor microenvironment appears crucial. We will discuss the role of innate effectors and cancer therapies in the process of defense against tumor cells.

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