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Binding of estrogenic compounds to recombinant estrogen receptor-alpha: application to environmental analysis.

Archive ouverte | Pillon, Arnaud | CCSD

International audience. Estrogenic activity in environmental samples could be mediated through a wide variety of compounds and by various mechanisms. High-affinity compounds for estrogen receptors (ERs), such as nat...

Estrogenic activity of cosmetic components in reporter cell lines. Estrogenic activity of cosmetic components in reporter cell lines: parabens, UV screens, and musks

Archive ouverte | Gomez, Elena | CCSD

International audience. In this work, the estrogenic effects of three classes of substances included in cosmetic formulations-parabens, ultraviolet (UV) screens, and musk fragrances-were studied. Their estrogenic ac...

Identification of new human pregnane X receptor ligands among pesticides using a stable reporter cell system

Archive ouverte | Lemaire, Géraldine | CCSD

International audience. Pregnane X receptor (PXR, NR1I2) is activated by various chemically unrelated compounds, including environmental pollutants and drugs. We proceeded here to in vitro screening of 28 pesticides...

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