The immunomodulatory properties of mesenchymal stromal cells isolated from the synovial fluid of human osteoarthritic joints

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Maillard, N. | Cikankowitz, A. | Grimandi, G. | Gauthier, O. | Brouard, S. | Guicheux, J. | Degauque, N. | Vinatier, C.

Edité par CCSD ; Elsevier -

International audience. OA is a degenerative joint disease accompanied by inflammation, loss of cartilaginous matrix, fibrillation, formation of fissures, and ultimately complete loss of the cartilage surface. Current pharmacological therapies for OA provide, at best, symptomatic relief from pain but fail to prevent cartilage damage and subsequent destruction of other joints tissues. Facing this situation, Mesenchymal Stromal Cells (MSC) have generated a recent significant medical consideration since they have the ability to differentiate into various tissues (including cartilage, bone, fat…) and exhibit tissue-regenerative properties. Moreover, MSC display immunomodulatory properties that can be instrumental for the treatment of inflammation-associated OA symptoms. Whereas adherent cells from the synovial fluid (SFAC) of osteoarthritic joints have been proposed to meet the criteria of MSC (Jones, English et al. 2004), their immunomodulatory properties have not yet been characterized. With respect to the potential interest of isolating some multipotent and immuno-competent cells from OA joints, the present work aims at comparing the immunomodulatory properties of SFAC with those of MSC isolated from bone marrow (BM-MSC) and adipose tissue (ASC).

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