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Characterizing the evolution and phenotypic impact of ampliconic Y chromosome regions

Archive ouverte | A. Lucotte, Elise | CCSD

International audience. A major part of the human Y chromosome consists of palindromes with multiple copies of genes primarily expressed in testis, many of which have been claimed to affect male fertility. We examin...

Extraordinary selection on the human X chromosome associated with archaic admixture

Archive ouverte | Skov, Laurits | CCSD

International audience. Highlights d Strong reductions in X chromosome diversity among non-Africans d Positive selection spread long haplotypes across non-African populations d The selected haplotypes spread from a ...

Associations of autozygosity with a broad range of human phenotypes

Archive ouverte | Clark, David, J. | CCSD

International audience. In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained uncle...

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