Syracuse

Human Herpesvirus 8 Serological Markers and Viral Load in Patients with AIDS-Associated Kaposi's Sarcoma in Central African Republic

Archive ouverte

Duprez, Renan | Kassa-Kelembho, Eric | Plancoulaine, Sabine | Brière, Josette | Fossi, Mireille | Kobangue, Léon | Minsart, Pierre | Huerre, Michel | Gessain, Antoine

Edité par CCSD ; American Society for Microbiology -

International audience. Epidemic Kaposi's sarcoma (KS) is one of the most frequent types of cancer in several African countries; however, very few data are available on human herpesvirus 8 (HHV-8) markers in KS patients from Central Africa. In a series of 36 AIDS-KS cases from Central African Republic, we showed, using a real-time PCR quantitative assay, the high frequency (82%) of detectable HHV-8 DNA in peripheral blood mononuclear cells (PBMCs). We also found that the level of antibodies directed against lytic or latent HHV-8 antigens is not correlated to the amount of HHV-8 viral load in the PBMCs, and finally, we demonstrated a much higher viral load in tumoral skin lesions (6.07 log copies/μg DNA) than in unaffected skin (2.93 log copies/μg DNA) or in PBMCs (2.55 log copies/μg DNA).

• Description
• Sujet/Public
• Outil
• Outil d'anticipation
• Mémoire et thèse
• Gestion