Heparan sulfate functions are altered in the osteoarthritic cartilage

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Shamdani, Sara | Chantepie, Sandrine | Flageollet, Camille | Henni-Chebra, Nadia | Jouan, Yohann | Eymard, Florent | Haÿ, Eric | Cohen-Solal, Martine | Papy-Garcia, Dulce | Chevalier, Xavier | Albanese, Patricia

Edité par CCSD ; BMC -

Number: 1. International audience. Heparan sulfate (HS) proteoglycans (PG) may be found at the chondrocyte surface and in the pericellular cartilage matrix, and are involved in cell-cell and cell-matrix interactions. An important function of HS chains is to regulate cell fate through specific interactions with heparin-binding proteins (HBP) modulated by their complex sulfation pattern. Osteoarthritis (OA) is a joint disorder characterized by the degradation of articular cartilaginous extracellular matrix. The aim of this study was to investigate HS structure and functions in osteoarthritic cartilages compared to normal cartilages (controls).

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