Role of MSCs in Antitumor Drug Resistance

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Le Naour, Augustin | Couderc, Bettina

Edité par CCSD ; Academic Press -

International audience. Resistance to anticancer drugs is a major problem hindering the treatment of many cancers. The tumor microenvironment can modulate the efficacy of chemotherapy. Among the cells of this microenvironment, mesenchymal stem/stromal cells (MSCs) can confer to tumor cells resistance to many anticancer agents. Indeed, MSCs secrete into the extracellular medium factors such as stromal cell-derived factor-1 (SDF-1), interleukin (IL)-6, amino acids, growth differentiation factor 15 (GDF-15), fatty acids, and ligands of Wnt and Notch signaling pathways that are able to induce chemoresistance of tumor cells. Mechanisms requiring direct cell/cell contact between MSCs and cancer cells may also be involved in MSC-induced chemoresistance of tumors. Such interactions induce, in tumor cells, an increase in the expression of antiapoptotic proteins and a quiescent state that together decrease the efficacy of cancer treatment and prevent the eradication of all tumor cells, later responsible for recurrence.

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