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2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors

Archive ouverte | Golebiowski, Adam | CCSD

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Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potent inhibitors of human arginases I and II for treatment of myocardial reperfusion injury

Archive ouverte | van Zandt, Michael C. | CCSD

Recent efforts to identify treatments for myocardial ischemia reperfusion injury have resulted in the discovery of a novel series of highly potent alpha,alpha-disubstituted amino acid-based arginase inhibitors. The lead candidate,...

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Archive ouverte | Mazur, Marzena | CCSD

This article highlights our work toward the identification of a potent, selective, and efficacious acidic mammalian chitinase (AMCase) inhibitor. Rational design, guided by X-ray analysis of several inhibitors bound to human chito...

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