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Monocytes generated by interleukin-6-treated human hematopoietic stem and progenitor cells secrete calprotectin that inhibits erythropoiesis

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Marchand, Valentine | Laplane, Lucie | Valensi, Louis | Plo, Isabelle | Aglave, Marine | Silvin, Aymeric | Pasquier, Florence | Porteu, Françoise | Vainchenker, William | Selimoglu-Buet, Dorothée | Droin, Nathalie | Raslova, Hana | Marcel, Virginie | Diaz, Jean-Jacques | Fontenay, Michaela | Solary, Eric

Edité par CCSD ; Elsevier -

International audience.

Highlights d IL-6 promotes the generation of monocytes secreting calprotectin d Calprotectin inhibits erythroid progenitor differentiation d JAK2-V617F amplifies hematopoietic effects of calprotectin d A calprotectin signature is detected in bone marrow cells of various diseases Authors

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