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BRN2 is a non-canonical melanoma tumor-suppressor

Archive ouverte | Hamm, Michael | CCSD

International audience. While the major drivers of melanoma initiation, including activation of NRAS/BRAF and loss of PTEN or CDKN2A, have been identified, the role of key transcription factors that impose altered t...

Thymine DNA glycosylase as a novel target for melanoma

Archive ouverte | Mancuso, Pietro | CCSD

International audience. Melanoma is an aggressive neoplasm with increasing incidence that is classified by the NCI as a recalcitrant cancer, i.e., a cancer with poor prognosis, lacking progress in diagnosis and trea...

Chromatin-Remodelling Complex NURF Is Essential for Differentiation of Adult Melanocyte Stem Cells

Archive ouverte | Koludrovic, Dana | CCSD

International audience. MIcrophthalmia-associated Transcription Factor (MITF) regulates melanocyte and melanoma physiology. We show that MITF associates the NURF chromatin-remodelling factor in melanoma cells. ShRNA...

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