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Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine N-oxide. Preuve d'une relation causale et modifiable entre la fonction rénale et la circulation du triméthylamine N-oxyde

Archive ouverte | Andrikopoulos, Petros | CCSD

International audience. Abstract The host-microbiota co-metabolite trimethylamine N -oxide (TMAO) is linked to increased cardiovascular risk but how its circulating levels are regulated remains unclear. We applied “...

Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism

Archive ouverte | Belda, Eugeni | CCSD

International audience. Objectives: Gut microbiota is a key component in obesity and type 2 diabetes, yet mechanisms and metabolites central to this interaction remain unclear. We examined the human gut microbiome’s...

Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine N -oxide with implications for heart and kidney disorders

Archive ouverte | Andrikopoulos, Petros | CCSD

Abstract Objectives The host-microbiota co-metabolite trimethylamine N -oxide (TMAO) is linked to increased thrombotic and cardiovascular risks. Here we, sought to i) characterize which host variables contribute to fasting serum T...

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