Amotosalen‐ HC l‐ UVA pathogen reduction does not alter poststorage metabolism of soluble CD 40 ligand, Ox40 ligand and interkeukin‐27, the cytokines that generally associate with serious adverse events

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Hamzeh-Cognasse, Hind | Laradi, S. | Osselaer, J. | Cognasse, F. | Garraud, O.

Edité par CCSD ; Wiley -

International audience. Platelets in therapeutic platelet concentrates are commonly acknowledged to release biologically active constituents during storage. This study examined the influence of photochemical pathogen reduction treatment ( PRT ) using amotosalen‐ HCl and UVA light vs. untreated control platelet components, on three factors recently reported to be associated with serious adverse events associated with platelet component (PC) transfusions: sCD 40L, IL‐27 and sOX 40 ligand. Levels of such cytokine‐like factors increased significantly during storage, but no significant difference was detected between PRT ‐ and control PC s. This suggests that occurrences of AEs are not directly influenced by PRT but rather may depend on alternate determinants.

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