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Oncology: From Empiricism to Integrative Biology. Oncology: From Empiricism to Integrative Biology: Inaugural Lecture delivered on Thursday 8 January 2015

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de Thé, Hugues

Edité par CCSD ; Éditions du Collège de France -

International audience. After decades of descriptive studies, the biology of cancer is undergoing a real revolution: with genetic approaches, researchers have identified many of the cell deregulations likely to drive tumours. A treatment combining arsenic and retinoic acid targets the protein responsible for promyelocytic leukaemia. This treatment, which has cured virtually all patients, gives hope that the in-depth understanding of carcinogenesis mechanisms may lead to new therapeutic approaches that could be transposed to other cancers.

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