WHO clinical criteria-based initiation of antiretroviral therapy: lessons from rural district hospitals in Cameroon with regard to 2009 revised WHO recommendations

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Kouanfack, Charles | Laborde-Balen, Gabrièle | Aghokeng Fobang, Avelin | Bourgeois, Anke | Dontsop, Marlise | Mben, Jean-Marc | Kazé, Serge | Mpoudi-Ngolé, Eitel | Koulla-Shiro, Sinata | Delaporte, Eric | Laurent, Christian

Edité par CCSD ; Wiley-Blackwell -

International audience. Ojective : To assess the proportion of patients infected with HIV with a CD4 count above 350 cells ⁄ mm 3 among those classified at WHO clinical stage 3 or 4 who initiated antiretroviral therapy in rural district hospitals in Cameroon to assess the 2009 revised WHO recommendations. methods Cross-sectional study in nine rural district hospitals where the treatment initiation is based on the WHO clinical criteria. The proportion of patients who were classified at stage 3 or 4 and who had a CD4 count >350 cells ⁄ mm 3 was assessed. results Of 458 patients included in 2006-2008 (women 70.5%; median age 37.0 years), 337 (73.6%) were classified at WHO clinical stage 3 and 121 (26.4%) at stage 4. Overall, 108 patients (23.6%) had a CD4 count >350 cells ⁄ mm 3 . Of them, 94 patients (20.5%) were classified at WHO clinical stage 3, and 14 (3.1%) were classified at WHO clinical stage 4.

conclusion The WHO clinical stages 3 and 4 were poorly correlated with the 'gold standard' of CD4 cell count. This study highlights the need to promote CD4 testing for assessing the patient eligibility.

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